2025 Cruises out of San Diego, California |
| There are 42 cruises that depart from San Diego, CA in the year 2025. Only one cruise line offers cruises that leave out of San Diego in 2025 - Holland America (total of 42 sailings, among them 20 on Nieuw Amsterdam, 15 on Zaandam and 5 on Koningsdam). You can see San Diego cruise schedule for 2025 in the table below. Be sure to look at the $/Day column to find cheap San Diego cruise deals in 2025. |
| Departure | Region | Itinerary | Ship | Days | Price | $/Day | Select |
| March 22 | Mexico | San Diego to Vancouver | Koningsdam | 14 | $1,664 | $119 |  |
| March 22 | Mexico | San Diego Round Trip | Zaandam | 11 | $1,339 | $122 | |
| March 29 | Pacific Coast | San Diego to Vancouver | Koningsdam | 7 | $799 | $114 | |
| March 29 | Hawaii | San Diego to Vancouver | Koningsdam | 24 | $2,919 | $122 | |
| April 2 | Mexico | San Diego Round Trip | Zaandam | 10 | $1,149 | $115 | |
| April 12 | Mexico | San Diego Round Trip | Zaandam | 14 | $1,624 | $116 | |
| April 12 | Mexico | San Diego Round Trip | Zaandam | 7 | $1,049 | $150 | |
| April 19 | Mexico | San Diego Round Trip | Zaandam | 14 | $1,579 | $113 | |
| April 19 | Mexico | San Diego Round Trip | Zaandam | 7 | $699 | $100 | |
| April 26 | Mexico | San Diego to Vancouver | Zaandam | 11 | $1,164 | $106 | |
| April 26 | Mexico | San Diego Round Trip | Zaandam | 7 | $949 | $136 | |
| April 26 | Pacific Coast | San Diego to Vancouver | Eurodam | 6 | $769 | $128 | |
| April 30 | Pacific Coast | San Diego to Vancouver | Nieuw Amsterdam | 4 | $404 | $101 | |
| May 3 | Pacific Coast | San Diego to Vancouver | Zaandam | 4 | $499 | $125 | |
| September 29 | Hawaii | San Diego Round Trip | Zaandam | 51 | $6,839 | $134 | |
| October 4 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,704 | $122 | |
| October 9 | Panama Canal | San Diego to Ft. Lauderdale | Eurodam | 17 | $2,689 | $158 | |
| October 11 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,334 | $95 | |
| October 11 | Pacific Coast | San Diego Round Trip | Nieuw Amsterdam | 7 | $794 | $113 | |
| October 18 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,639 | $117 | |
| October 18 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $729 | $104 | |
| October 21 | Pacific Coast | San Diego Round Trip | Koningsdam | 4 | $459 | $115 | |
| October 25 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $884 | $126 | |
| October 25 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,370 | $98 | |
| November 1 | Panama Canal | San Diego to Ft. Lauderdale | Koningsdam | 17 | $2,004 | $118 | |
| November 1 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,759 | $126 | |
| November 1 | Pacific Coast | San Diego Round Trip | Nieuw Amsterdam | 7 | $834 | $119 | |
| November 8 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,639 | $117 | |
| November 8 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $874 | $125 | |
| November 15 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,689 | $121 | |
| November 15 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $884 | $126 | |
| November 19 | Hawaii | San Diego Round Trip | Zaandam | 29 | $2,594 | $89 | |
| November 19 | Hawaii | San Diego Round Trip | Zaandam | 17 | $1,839 | $108 | |
| November 22 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $924 | $132 | |
| November 29 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 10 | $1,244 | $124 | |
| December 6 | Mexico | San Diego Round Trip | Zaandam | 12 | $1,394 | $116 | |
| December 6 | Hawaii | San Diego Round Trip | Zaandam | 29 | $2,954 | $102 | |
| December 9 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 11 | $1,129 | $103 | |
| December 18 | Hawaii | San Diego Round Trip | Zaandam | 17 | $2,239 | $132 | |
| December 20 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $2,289 | $164 | |
| December 20 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $1,089 | $156 | |
| December 27 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $1,274 | $182 | |
