2025 Cruises out of San Diego, California |
| There are 48 cruises that depart from San Diego, CA in the year 2025. Just two cruise lines offer cruises that leave out of San Diego in 2025 - Holland America (total of 47 sailings, among them 20 on Nieuw Amsterdam, 16 on Zaandam and 9 on Koningsdam) and Norwegian (NCL) (just 1 sailing on Norwegian Jade). You can see San Diego cruise schedule for 2025 in the table below. Be sure to look at the $/Day column to find cheap San Diego cruise deals in 2025. |
| Departure | Region | Itinerary | Ship | Days | Price | $/Day | Select |
| January 3 | Panama Canal | San Diego to Ft. Lauderdale | Zaandam | 15 | $1,899 | $127 |  |
| January 11 | Hawaii | San Diego Round Trip | Koningsdam | 17 | $1,909 | $112 | |
| January 28 | Hawaii | San Diego Round Trip | Koningsdam | 18 | $1,939 | $108 | |
| February 15 | Hawaii | San Diego Round Trip | Koningsdam | 35 | $4,929 | $141 | |
| March 22 | Mexico | San Diego Round Trip | Zaandam | 11 | $1,294 | $118 | |
| March 22 | Mexico | San Diego to Vancouver | Koningsdam | 14 | $1,664 | $119 | |
| March 22 | Mexico | San Diego Round Trip | Koningsdam | 7 | $1,199 | $171 | |
| March 29 | Hawaii | San Diego to Vancouver | Koningsdam | 24 | $2,639 | $110 | |
| March 29 | Pacific Coast | San Diego to Vancouver | Koningsdam | 7 | $799 | $114 | |
| April 2 | Mexico | San Diego Round Trip | Zaandam | 10 | $1,049 | $105 | |
| April 12 | Mexico | San Diego Round Trip | Zaandam | 14 | $1,584 | $113 | |
| April 12 | Mexico | San Diego Round Trip | Zaandam | 7 | $799 | $114 | |
| April 19 | Pacific Coast | San Diego Round Trip | Zaandam | 7 | $899 | $128 | |
| April 19 | Mexico | San Diego Round Trip | Zaandam | 14 | $1,594 | $114 | |
| April 26 | Mexico | San Diego to Vancouver | Zaandam | 11 | $1,164 | $106 | |
| April 26 | Mexico | San Diego Round Trip | Zaandam | 7 | $834 | $119 | |
| April 26 | Pacific Coast | San Diego to Vancouver | Eurodam | 6 | $769 | $128 | |
| April 30 | Pacific Coast | San Diego to Vancouver | Nieuw Amsterdam | 4 | $404 | $101 | |
| May 3 | Pacific Coast | San Diego to Vancouver | Zaandam | 4 | $419 | $105 | |
| September 29 | Hawaii | San Diego Round Trip | Zaandam | 51 | $7,109 | $139 | |
| October 4 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,704 | $122 | |
| October 9 | Panama Canal | San Diego to Ft. Lauderdale | Eurodam | 17 | $2,689 | $158 | |
| October 11 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,779 | $127 | |
| October 11 | Pacific Coast | San Diego Round Trip | Nieuw Amsterdam | 7 | $1,029 | $147 | |
| October 18 | Panama Canal | San Diego to Miami | Norwegian Jade | 14 | $2,018 | $144 | |
| October 18 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $874 | $125 | |
| October 18 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,639 | $117 | |
| October 21 | Pacific Coast | San Diego Round Trip | Koningsdam | 4 | $559 | $140 | |
| October 25 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $884 | $126 | |
| October 25 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,764 | $126 | |
| November 1 | Panama Canal | San Diego to Ft. Lauderdale | Koningsdam | 17 | $2,229 | $131 | |
| November 1 | Pacific Coast | San Diego Round Trip | Nieuw Amsterdam | 7 | $1,009 | $144 | |
| November 1 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,759 | $126 | |
| November 8 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,639 | $117 | |
| November 8 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $874 | $125 | |
| November 15 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $1,689 | $121 | |
| November 15 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $884 | $126 | |
| November 19 | Hawaii | San Diego Round Trip | Zaandam | 17 | $1,919 | $113 | |
| November 19 | Hawaii | San Diego Round Trip | Zaandam | 29 | $3,109 | $107 | |
| November 22 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $924 | $132 | |
| November 29 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 10 | $1,244 | $124 | |
| December 6 | Mexico | San Diego Round Trip | Zaandam | 12 | $1,394 | $116 | |
| December 6 | Hawaii | San Diego Round Trip | Zaandam | 29 | $3,699 | $128 | |
| December 9 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 11 | $1,284 | $117 | |
| December 18 | Hawaii | San Diego Round Trip | Zaandam | 17 | $2,509 | $148 | |
| December 20 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 14 | $2,289 | $164 | |
| December 20 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $1,184 | $169 | |
| December 27 | Mexico | San Diego Round Trip | Nieuw Amsterdam | 7 | $1,274 | $182 | |
